Key factors in mTOR regulation
نویسندگان
چکیده
منابع مشابه
mTOR regulation of autophagy.
Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although T...
متن کاملmTOR and lysosome regulation
Lysosomes are key cellular organelles that play a crucial role in catabolism by degrading extracellular and intracellular material. It is, therefore, very intriguing that mTORC1 (mechanistic target of rapamycin complex 1), a major promoter of anabolic processes, localizes in its active form to the surface of lysosomes. In recent years, many exciting observations have revealed a tightly regulate...
متن کاملSenescence regulation by mTOR.
The senescence program is activated in response to diverse stress stimuli potentially compromising genetic stability and leads to an irreversible cell cycle arrest. The mTOR pathway plays a crucial role in the regulation of cell metabolism and cellular growth. The goal of this chapter is to present evidence linking these two processes, which have one common regulator-the tumor suppressor p53. W...
متن کاملRegulation of tau by mTor
Previous evidence from post-mortem Alzheimer disease (AD) brains and drug (especially rapamycin)-oriented in vitro and in vivo models implicated an aberrant accumulation of the mammalian target of rapamycin (mTor) signaling in tangle bearing neurons in AD brains and its role in the formation of abnormally hyperphosphorylated tau. Compelling evidence indicated that the sequential molecular event...
متن کاملIdentifying and Analyzing Key Factors Affecting Singleness in Iran
In the past decades, social structures and institutions, including families, have been transformed by phenomena such as modernism, globalization and the expansion of communication networks. Transformation in the pattern of marriage and the age of marriage is one of the domains affected by these changes. In Iran, delay in marriage and increased Singleness have increased in recent years. The pur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2009
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-009-0163-7